Biological Crystallography Journal Club (BCJC)

Course# MIC-789

Course Master - Mark R. Walter

Time: Thursdays from 1:30-2:30PM   CBSE 2^nd Floor Library

The BCJC revolves around a weekly literature review that focuses on papers that use single crystal X-ray diffraction techniques to solve important questions in structural biology.  The participants are encouraged to focus on the methods that allow the problems to be solved.  These areas include novel methods of protein expression and purification, crystallization, X-ray data collection, phasing, refinement, and structure analysis methods.  Critiques are made on the quality of the structures presented and how structural information is best presented in scientific journals.  Emphasis is also placed on novel techniques that synergize with crystallographic techniques leading to new insights into protein structure and function. As needed, the journal club will focus on historically important papers in methods development of protein crystallography. Guidelines for presentations and student expectations are found here.

FALL 2009 Schedule

Speaker	Date	Papers
	9-10	-
TBA	9-17	Organize
Baldeep	9-24	http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.biophys.050708.133655?cookieSet=1&journalCode=biophys Crystallizing Membrane Proteins for Structure Determination: Use of Lipidic Mesophases PRESENTATION
Baldeep	10-1	http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-4WH1H65-2&_user=446477&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000020378&_version=1&_urlVersion=0&_userid=446477&md5=7dcc5f142971bc3c49d3c77f5c3ddb3b X-Ray Structures of the Hexameric Building Block of the HIV Capsids
Tao	10-8	Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS) Greg L Hura1,6, Angeli L Menon2,6, Michal Hammel1,6, Robert P Rambo1, Farris L Poole II2, Susan E Tsutakawa3, Francis E Jenney Jr2,4, Scott Classen1, Kenneth A Frankel1, Robert C Hopkins2, Sung-jae Yang2, Joseph W Scott2, Bret D Dillard2, Michael W WAdams2 & John A Tainer3,5 http://www.nature.com/nmeth/journal/v6/n8/pdf/nmeth.1353.pdf PRESENTATION
No meeting	10-15
Baru	10-22
WenJun	10-29	Subunit Architecture of Multiprotein Assemblies Determined Using Restraints from Gas-Phase Measurements Tara L. Pukala^1, Brandon T. Ruotolo^1, Min Zhou^1, Argyris Politis^1, Raluca Stefanescu^2, Julie A. Leary^2 and Carol V. Robinson^1^,^, http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VSR-4X6DSSG-D&_user=446477&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000020378&_version=1&_urlVersion=0&_userid=446477&md5=1a522ea46a14c9db2847f13d3be1929a
No meeting	11-5
Tao	11-12	Direct observation of the binding state of the kinesin head to the microtubule Nicholas R. Guydosh1 & Steven M. Block2,3 http://www.nature.com/nature/journal/v461/n7260/pdf/nature08259.pdf
Baru	11-19	http://www.ncbi.nlm.nih.gov/pubmed/19799414?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1 Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays‡ Robert Godemann,*,§ James Madden, Joachim Kr€amer,§ Myron Smith, Ulrike Fritz,§ Thomas Hesterkamp,§ John Barker, Sabine H€oppner,^ David Hallett, Andrea Cesura,§ Andreas Ebneth,§ and John Kemp§
No meeting	11-26
WenJun	12-3

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