Biological Crystallography Journal Club (BCJC)

Course# MIC-789

Course Master - Mark R. Walter

Time: Thursdays from 1:15-2:15PM   CBSE  2nd Floor Library

The BCJC revolves around a weekly literature review that focuses on papers that use single crystal X-ray diffraction techniques to solve important questions in structural biology.  The participants are encouraged to focus on the methods that allow the problems to be solved.  These areas include novel methods of protein expression and purification, crystallization, X-ray data collection, phasing, refinement, and structure analysis methods.  Critiques are made on the quality of the structures presented and how structural information is best presented in scientific journals.  Emphasis is also placed on novel techniques that synergize with crystallographic techniques leading to new insights into protein structure and function.  As needed, the journal club will focus on historically important papers in methods development of protein crystallography.  Guidelines for presentations and student expectations are found here.

WINTER/SPRING 2007 Schedule

Speaker

Date

Papers

TBA

1-18

 

TBA

1-25

 

David S.

2-1

Subunit exchange of multimeric protein complexes. Sobott et al. (2002) 38921-38929

       -

2-8

 No Meeting

Wenjun C.

2-15

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Qui et al. Nat. Struc. Biol. (2007) 106-113.

TBA

2-22

 

Altaria D.

3-1

Structural analysis of kasugamycin inhibition of translation  Schuwirth et al Nat. Struc Biol (2006) 879-886.

TBA

3-8

No Meeting

       -

3-15

No Meeting

Christopher A

3-22

 Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction.  Banerji et al. Nat. Struc. Biol. (2007) 234-239.

Altaria D.

3-29

 Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Shiau et al Cell (2006) 329-340.

Wenjun C.

4-5

 Structure of the protein phosphatase 2A holoenzyme.  Xu et al. Cell (2006) 1239-1251.

David S.

4-12

 Mapping the Structure of Folding Cores in TIM Barrel Proteins by Hydrogen Exchange Mass Spectrometry: The Roles of Motif and Sequence for the Indole-3-glycerol Phosphate Synthase from Sulfolobus solfataricus.  Gu et al. JMB (2007) 582-594

TBA

4-19

 

 

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