Structural
Biology in the Walter Lab
Welcome
to the laboratory homepage of Mark R. Walter at the University
of Alabama at Birmingham. The Laboratory is
interested in understanding the structural basis of molecular recognition
events that subsequently lead to cellular signal transduction. Currently,
we are studying members of the alpha helical cytokine family Interferon-gamma
(The IFN-gamma receptor complex is shown above as a space filling model as
might be observed on the cell membrane), interferon-alpha, and interleukin-10,
their receptors, and various intracellular signaling molecules using single
crystal X-ray diffraction, mutagenesis, mass spectrometry, analytical
ultracentrifugation, and surface plasmon resonance techniques. Positions
are also available in cytokine structure-function. Please see
"positions available" for more information.
Webpage last updated 11-21-2006 Top of the Page