Structural
Biology in the Walter Lab
Welcome to the laboratory homepage of Mark R. Walter at the University
of Alabama at Birmingham. The Laboratory is interested
in understanding the structural basis of molecular recognition events that
subsequently lead to cellular signal transduction. Currently, we are
studying members of the alpha helical cytokine family Interferon-gamma (The
IFN-gamma receptor complex is shown above as a space filling model as might be
observed on the cell membrane), interferon-alpha, and interleukin-10, their
receptors, and various intracellular signaling molecules using single crystal
X-ray diffraction, mutagenesis, mass spectrometry, analytical
ultracentrifugation, and surface plasmon resonance techniques. Positions
are also available in cytokine structure-function. Please see
"positions available" for more information.
Webpage last updated 8-20-2009 Top of the Page